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Lamellar granule : ウィキペディア英語版 | Lamellar granule
Lamellar granules (otherwise known as membrane-coating granules (MCGs), lamellar bodies, keratinosomes or Odland bodies) are secretory organelles found in type II pneumocytes and keratinocytes. They are oblong structures, appearing about 300-400 nm in width and 100-150 nm in length in transmission electron microscopy images. Lamellar granules fuse with the cell membrane and release their contents into the extracellular space.〔 〕 == Role in lungs == In pneumocytes, the choline-based phospholipids that are stored in the lamellar bodies serve as pulmonary surfactant after being released from the cell. In 1964, using transmission electron microscopy, which at that time was a relatively new tool for ultrastructural elucidation, John Balis identified the presence of lamellar bodies in type II pneumocytes, and further noted that upon their exocytotic migration to the alveolar surface, lamellar contents would uniformly unravel and spread along the circumference of the alveolus, thus lowering surface tension and similarly, the required alveolar inflation force.〔Balis J.U., Conen P.E. (Oct 1964), "The Role of Alveolar Inclusion Bodies in the Developing Lung." ''Lab Invest''. 13:1215-29. (PMID 14212352 ).〕
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